IgA Plasma Cells
Gene co-expression module in Plasma cells
| Category | IgA production |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 5 of 10 genes have a known function matching the annotation |
Why this annotation
Hub genes TNFRSF17 (BCMA), JCHAIN, IGHA1, IGHA2 are canonical IgA plasma cell markers. TNFRSF13B (TACI) supports plasma cell survival signaling. Module is strongly downregulated in inflammation and upregulated in UC remission, consistent with IgA plasma cell homeostasis disrupted during active IBD. ENAM and WNT10A are weakly associated peripheral members. Neighbor context: sits adjacent to IgG module (M43) and ER processing module (M1), consistent with isotype-specific immunoglobulin production programs.
Genes
Most correlated modules
- IgA Plasma Maturation · correlation 0.51
- Heat Shock Response · correlation 0.35
- Stress-induced Quiescence · correlation 0.33
- ER Stress UPR · correlation 0.32
- Tissue Residency Activation · correlation 0.29
- Immediate Early TFs · correlation 0.29
- AP-1 Immediate Early · correlation 0.26
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.