IgA Plasma Maturation
Gene co-expression module in Plasma cells
| Category | Tissue residency |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 16 genes have a known function matching the annotation |
Why this annotation
Hub genes include KLF4 (master regulator of IgA plasma cell tissue residency and differentiation), CADPS2 (calcium-dependent secretory vesicle protein), TIMP2 (tissue inhibitor of metalloproteinases), AMN (endocytic receptor), and ST3GAL6 (sialylation enzyme modifying surface glycans). The module is enriched in igA_plasma cells and significantly decreased with inflammation in both UC and CD, consistent with loss of mature tissue-resident IgA plasma cell identity during active disease. CTHRC1 and CD9 further support a tissue-anchored, mature plasma cell state. KLF4 is the strongest anchor for tissue residency in IgA plasma cells.
Genes
Most correlated modules
- Heat Shock Response · correlation 0.57
- Stress-induced Quiescence · correlation 0.54
- IgA Plasma Cells · correlation 0.51
- AP-1 Immediate Early · correlation 0.50
- Immediate Early TFs · correlation 0.47
- ER Stress UPR · correlation 0.46
- Glucocorticoid Response · correlation 0.41
- Tissue Residency Activation · correlation 0.39
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.