Tissue Residency Activation
Gene co-expression module in Plasma cells
| Category | Tissue residency |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 18 genes have a known function matching the annotation |
Why this annotation
Top hub genes RGS1 and CD69 are canonical tissue residency markers in lymphocytes and plasma cells. NR4A3 is an activation-induced nuclear receptor. RGS2 and SOCS3 are negative regulators of G-protein and cytokine signaling respectively, consistent with a post-activation dampening program. CCL3, CCL4, CCL5 are inflammatory chemokines indicating recent activation. GABARAPL1 links to autophagy. BCL2 supports survival. The module is significantly decreased with inflammation (especially UC), suggesting that this tissue-resident activation-response state is lost or replaced during active IBD. The igA_plasma and uniform enrichment pattern, combined with RGS1/CD69, strongly supports a tissue residency activation program.
Genes
Most correlated modules
- Glucocorticoid Response · correlation 0.87
- AP-1 Immediate Early · correlation 0.76
- Immediate Early TFs · correlation 0.69
- Heat Shock Response · correlation 0.63
- ER Stress UPR · correlation 0.59
- Stress-induced Quiescence · correlation 0.49
- IgA Plasma Maturation · correlation 0.39
- IgA Plasma Cells · correlation 0.29
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.