ER Stress UPR
Gene co-expression module in Plasma cells
| Category | Protein processing & ER |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 6 of 7 genes have a known function matching the annotation |
Why this annotation
HERPUD1 (homocysteine-inducible ER stress protein with ubiquitin-like domain) and DDIT3 (CHOP/GADD153) are canonical UPR/ER stress markers. DNAJB9 (ERdj4) is an ER-localized HSP40 co-chaperone induced by ER stress. CCPG1 is an ER-phagy receptor. DDIT4 (REDD1) is induced by ER stress and inhibits mTORC1. CEBPB is a transcription factor activated downstream of ER stress and DDIT3. BEX2 is stress-responsive. This module represents the ER stress/UPR program, complementing neighbor M48 (cytoplasmic HSP chaperones) — together they form the complete proteostasis stress response in igA plasma cells. The moderate coherence with weak memberships for DDIT4, DNAJB9, BEX2, CCPG1 suggests some peripheral members.
Genes
Most correlated modules
- AP-1 Immediate Early · correlation 0.67
- Glucocorticoid Response · correlation 0.63
- Heat Shock Response · correlation 0.63
- Tissue Residency Activation · correlation 0.59
- Stress-induced Quiescence · correlation 0.54
- Immediate Early TFs · correlation 0.54
- ER Protein Processing · correlation 0.46
- IgA Plasma Maturation · correlation 0.46
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.