Respiratory Chain Complex I
Gene co-expression module in Tuft cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 6 of 13 genes have a known function matching the annotation |
Why this annotation
NDUFB4, NDUFA2, NDUFC1, UQCR11 are subunits of mitochondrial respiratory chain Complex I and Complex III respectively. CYB5A (cytochrome b5) is involved in electron transfer. SLIRP stabilizes mitochondrial mRNAs. SRP14 and SSR4 are signal recognition particle components for ER targeting. DAD1 is an oligosaccharyltransferase subunit. LAMTOR5 is part of the Ragulator complex (mTORC1). NAA38 is an N-terminal acetyltransferase subunit. MYL12B is myosin light chain. CYSTM1 is a cysteine-rich transmembrane protein. The dominant program is mitochondrial respiratory chain (Complex I/III), closely related to neighbor M39. The ER/SRP components (SRP14, SSR4, DAD1) are secondary.
Genes
Most correlated modules
- Sulfur Redox Detox · correlation 0.98
- Mitochondrial Proteostasis · correlation 0.98
- Intestinal Progenitor Differentiation · correlation 0.97
- Pre-tuft Metabolic Identity · correlation 0.97
- Mitochondrial OxPhos/TCA · correlation 0.95
- Pre-tuft Progenitor State · correlation 0.94
- OxPhos Pre-tuft · correlation 0.94
- Oxidative Stress Response · correlation 0.93
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.