Mitochondrial OxPhos/TCA
Gene co-expression module in Tuft cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 10 of 14 genes have a known function matching the annotation |
Why this annotation
This module is dominated by mitochondrial OxPhos and TCA cycle genes: NDUFA10 and NDUFB5 (Complex I subunits), COX14 and COX7A2L (Complex IV assembly/subunit), MRPS16 and MRPL51 (mitochondrial ribosomes), IDH2 (isocitrate dehydrogenase, TCA), MDH1 (malate dehydrogenase, TCA), TOMM22 (mitochondrial outer membrane translocase), ATP1B3 (Na/K-ATPase). CD99 and CD81 are surface markers enriched in pre_tuft. ARHGDIA (Rho GDI) and GPR160 are signaling components. The core identity is mitochondrial biogenesis and OxPhos, consistent with the high metabolic demands of differentiating tuft progenitors. Neighbor M81 shares the same OxPhos theme, confirming this neighborhood.
Genes
Most correlated modules
- Pre-tuft Progenitor State · correlation 0.99
- Sulfur Redox Detox · correlation 0.99
- Intestinal Progenitor Differentiation · correlation 0.98
- Pre-tuft Metabolic Identity · correlation 0.97
- Mitochondrial Proteostasis · correlation 0.96
- Oxidative Stress Response · correlation 0.96
- Respiratory Chain Complex I · correlation 0.95
- Antimicrobial Defense · correlation 0.91
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.