Sulfur Redox Detox
Gene co-expression module in Tuft cells
| Category | Stress |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 11 genes have a known function matching the annotation |
Why this annotation
Hub genes TST and MPST are both sulfurtransferases involved in cyanide/sulfur detoxification, MGST2 is a glutathione S-transferase (microsomal), and SCP2 is a lipid/sterol transfer protein. Supporting genes include KDELR2 (ER), RHOA (cytoskeletal signaling), MYL12A (myosin), HNRNPK and FAM120A (RNA binding), CNBP (zinc finger transcription), NOP10 (ribosome). The dominant biological theme is sulfur/thiol detoxification and redox metabolism, all enriched in pre_tuft cells. The treatment-positive delta suggests this program is suppressed during active inflammation.
Genes
Most correlated modules
- Intestinal Progenitor Differentiation · correlation 0.99
- Mitochondrial OxPhos/TCA · correlation 0.99
- Respiratory Chain Complex I · correlation 0.98
- Pre-tuft Metabolic Identity · correlation 0.98
- Pre-tuft Progenitor State · correlation 0.98
- Mitochondrial Proteostasis · correlation 0.97
- Oxidative Stress Response · correlation 0.96
- Nucleolar RNA Processing · correlation 0.92
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.