Intestinal Progenitor Differentiation
Gene co-expression module in Tuft cells
| Category | Epithelial development |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 9 genes have a known function matching the annotation |
Why this annotation
CDX2 is a master intestinal transcription factor critical for tuft cell identity and intestinal epithelial differentiation. LAMTOR1 is a key mTORC1 lysosomal scaffold regulating nutrient sensing and differentiation. DECR1 encodes 2,4-dienoyl-CoA reductase (mitochondrial fatty acid oxidation). SRSF9 (splicing), TRMT112 (tRNA/rRNA methylation), MRPL13 (mitoribosome), ARF6 (vesicle trafficking), TXNDC17 (thioredoxin domain), TM9SF3 (transmembrane). CDX2 anchors this as a tuft/intestinal progenitor differentiation module with metabolic support. Strong pre_tuft enrichment and positive treatment response support a progenitor differentiation identity.
Genes
Most correlated modules
- Pre-tuft Progenitor State · correlation 0.99
- Sulfur Redox Detox · correlation 0.99
- Mitochondrial OxPhos/TCA · correlation 0.98
- Respiratory Chain Complex I · correlation 0.97
- Pre-tuft Metabolic Identity · correlation 0.96
- Mitochondrial Proteostasis · correlation 0.95
- Antimicrobial Defense · correlation 0.93
- Oxidative Stress Response · correlation 0.92
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.