Pre-tuft Progenitor State
Gene co-expression module in Tuft cells
| Category | Epithelial development |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 11 of 15 genes have a known function matching the annotation |
Why this annotation
ARL14 (14.1x pre_tuft enrichment) is a small GTPase associated with tuft/secretory cell identity. CDK6 is a cell cycle kinase active in G1 progenitor states. HOXB13 is a transcription factor involved in intestinal epithelial identity. NEDD9 (HEF1) mediates cell adhesion and migration signaling. TOMM40 and VDAC3 are mitochondrial import/channel proteins. NDUFA9 (Complex I), GOT2 (aspartate aminotransferase/TCA), OSTC and SSR3 (ER translocon), MRPL1 (mitoribosome), PTP4A1 (phosphatase promoting proliferation), YIF1A (Golgi), NUDT8 (nudix hydrolase), SLC39A8 (zinc transporter). The combination of CDK6, HOXB13, ARL14, and NEDD9 points to a pre-tuft progenitor cell cycle/commitment state with mitochondrial biogenesis support.
Genes
Most correlated modules
- Intestinal Progenitor Differentiation · correlation 0.99
- Mitochondrial OxPhos/TCA · correlation 0.99
- Sulfur Redox Detox · correlation 0.98
- Respiratory Chain Complex I · correlation 0.94
- Pre-tuft Metabolic Identity · correlation 0.94
- Antimicrobial Defense · correlation 0.94
- IFN-Tuft Activation · correlation 0.93
- Mitochondrial Proteostasis · correlation 0.93
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.