ADA2 — Adenosine deaminase 2
ADA2 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ADA2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | TCR signaling TCR/AP1/NFKb pathway | ACVR1C, ANK3, CAMK4, CHD7, GCLM, GNAO1, MPP7, NME4 +15 more | View in SCUBA |
| Gamma-delta T cells | T Cell Identity Program T cell maturation | ADAM10, ARHGAP12, ATM, LPP, NLRC5, PIKFYVE, PJA2, PRKCQ +5 more | |
| Macrophages | Innate Antiviral Sensing Innate immunity | ADPRH, ALDH9A1, APOBEC3C, BST2, C2, CAT, CD4, CHID1 +26 more | View in SCUBA |
About the gene
| Synonyms | ADGF, CECR1, IDGFL |
|---|---|
| Chromosome | 22: 17178790-17258235 |
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins |
| Molecular function | Heparin-binding, Hydrolase |
Function
Adenosine deaminase that may contribute to the degradation of extracellular adenosine, a signaling molecule that controls a variety of cellular responses. Requires elevated adenosine levels for optimal enzyme activity. Binds to cell surfaces via proteoglycans and may play a role in the regulation of cell proliferation and differentiation, independently of its enzyme activity.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.