SCUBA

LPP — LIM domain containing preferred translocation partner in lipoma

LPP belongs to a gene co-expression module in 9 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

LPP's module in each cell type

Cell typeModuleShares the module with
CD19⁺ B cellsDark-zone GC B-cell
B cell maturation
BRWD1, CCDC144A, CCDC88A, CD38, FGD6, MYBL1, MYO1E, RAPGEF5 +2 moreView in SCUBA
EnterocytesFocal adhesion actin
Migration & adhesion
BAZ2B, CARMIL1, COP1, FRYL, KIF13A, MYO6, PALLD, PTK2 +4 moreView in SCUBA
FibroblastsMyofibroblast Contractile
Cytoskeletal
ACTA2, CCDC107, CFL2, CSRP1, FLNA, ILK, MSRB3, MYL9 +7 moreView in SCUBA
Gamma-delta T cellsT Cell Identity Program
T cell maturation
ADA2, ADAM10, ARHGAP12, ATM, NLRC5, PIKFYVE, PJA2, PRKCQ +5 more
Lymphatic endothelialFocal Adhesion Migration
migration & adhesion
BIRC6, CDC42BPA, DOCK1, EIF4G3, GNAQ, NF1, PAM, PTK2 +2 moreView in SCUBA
MacrophagesRho GTPase Signaling
Cytoskeletal
ABHD18, AFF1, ARHGEF7, DIP2B, DNAAF9, DOCK11, EVI5, GNAQ +24 moreView in SCUBA
Mucosal-associated invariant T cellLymphocyte Migration
migration & adhesion
AP3B1, ATP9B, BIRC6, BTBD9, CEP350, DOCK11, DOCK2, ERBIN +8 more
PericytesQuiescent Pericyte State
Developmental
ARID5B, C1QTNF1, CPE, HOPX, ITGA7, MT2A, MTHFD2, SLIT3 +1 moreView in SCUBA
Smooth muscle cellsMatrisome Regulators
ECM remodeling
ITM2C, LUM, NBL1, PMP22, S100A13, TCEAL4, TIMP2, TMEM176B +1 moreView in SCUBA

About the gene

Chromosome3: 188153284-188890671
Predicted locationIntracellular
Essential geneNo
Protein classCancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins
Molecular functionActivator
Biological processCell adhesion

Function

May play a structural role at sites of cell adhesion in maintaining cell shape and motility. In addition to these structural functions, it may also be implicated in signaling events and activation of gene transcription. May be involved in signal transduction from cell adhesion sites to the nucleus allowing successful integration of signals arising from soluble factors and cell-cell adhesion sites. Also suggested to serve as a scaffold protein upon which distinct protein complexes are assembled in the cytoplasm and in the nucleus

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.