Innate Antiviral Sensing
Gene co-expression module in Macrophages
| Category | Innate immunity |
|---|---|
| Genes | 35 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 11 of 35 genes have a known function matching the annotation |
Why this annotation
Hub genes include STING1 (cytosolic DNA sensing), GBP4 (IFN-induced GTPase), BST2 (IFN-stimulated tetherin), HLA-DMB (MHC-II peptide loading), RFX5 (MHC-II transcription factor), C2 and SERPING1 (complement), LGALS3BP and RNASE6 (innate immune effectors). These collectively point to an interferon-driven innate immune/antiviral macrophage program. GIMAP4, GIMAP6, and CD4 are T-cell-associated genes that may reflect ambient RNA or weak T-cell contamination, but the dominant program across the majority of genes is macrophage innate immune/antiviral sensing. All genes show weak membership and uniform expression, consistent with a loosely defined but biologically coherent innate immune module.
Genes
ADA2, ADPRH, ALDH9A1, APOBEC3C, BST2, C2, CAT, CD4, CHID1, CREBL2, CYBRD1, DPYSL2, GBP4, GIMAP2, GIMAP4, GIMAP6, GPR34, HHEX, HLA-DMB, LGALS3BP, LIPA, PCYOX1, PLEKHO1, RASSF4, RFX5, RNASE6, SCRN1, SELPLG, SERPING1, SGPL1, SORBS3, STING1, TK2, TMEM37, TNFSF10
Most correlated modules
- Endosomal Membrane Trafficking · correlation 0.94
- Retromer Endosomal Sorting · correlation 0.93
- Lysosomal Hydrolase Program · correlation 0.90
- Macrophage Identity · correlation 0.88
- Macrophage Proliferation · correlation 0.87
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.