T Cell Identity Program
Gene co-expression module in Gamma-delta T cells
| Category | T cell maturation |
|---|---|
| Genes | 14 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 14 genes have a known function matching the annotation |
Why this annotation
PTPRC (CD45, master lymphocyte phosphatase), PRKCQ (PKC-theta, critical T cell signaling kinase), NLRC5 (MHC-I transactivator), ATM (DNA damage/genomic stability), ADA2 (adenosine deaminase 2, purinergic signaling), ADAM10 (NOTCH/CD44 sheddase), PIKFYVE (endolysosomal PI kinase), UTRN (utrophin, cytoskeletal scaffold at immunological synapse). This module captures core T cell identity/signaling maintenance genes including CD45-mediated TCR threshold setting and PKC-theta activation, with cytoskeletal (UTRN, ARHGAP12, LPP) support.
Genes
ADA2, ADAM10, ARHGAP12, ATM, LPP, NLRC5, PIKFYVE, PJA2, PRKCQ, PTPRC, TRERF1, UTRN, VCPIP1, ZNF142
Most correlated modules
- TCR Activation Signaling · correlation 0.87
- mTOR-Exocyst Signaling · correlation 0.84
- ER Antigen Processing · correlation 0.84
- T cell Identity Signaling · correlation 0.83
- Butyrophilin gd Activation · correlation 0.81
- Chromatin Epigenetic Regulation · correlation 0.81
- Vesicular Trafficking · correlation 0.80
- TGF-β Migration Program · correlation 0.77
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.