NLRC5 — NLR family CARD domain containing 5
NLRC5 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
NLRC5's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | IFN-gamma STAT1 signaling Inflammation | C2, ENSG00000283782, GBP4, HLA-E, LAP3, PARP8, STAT1, TAP1 +1 more | View in SCUBA |
| Gamma-delta T cells | T Cell Identity Program T cell maturation | ADA2, ADAM10, ARHGAP12, ATM, LPP, PIKFYVE, PJA2, PRKCQ +5 more |
About the gene
| Synonyms | CLR16.1, FLJ21709, NOD27 |
|---|---|
| Chromosome | 16: 56989485-57083531 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Biological process | Immunity, Innate immunity |
Function
Probable regulator of the NF-kappa-B and type I interferon signaling pathways. May also regulate the type II interferon signaling pathway. Plays a role in homeostatic control of innate immunity and in antiviral defense mechanisms.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.