ADSS2 — Adenylosuccinate synthase 2
ADSS2 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ADSS2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | T Cell Exhaustion Exhaustion | ACADVL, ACSS1, B4GALT3, CDK11A, CHP1, CNOT2, CNOT8, CRELD2 +20 more | |
| Macrophages | Ubiquitin-Proteasome System Housekeeping | ACTR10, ATXN10, CAND1, CYRIB, DKC1, DPM1, EIF4E, HSPA4 +18 more | View in SCUBA |
About the gene
| Synonyms | ADSS |
|---|---|
| Chromosome | 1: 244408494-244451909 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Enzymes, Essential proteins, Metabolic proteins, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Ligase |
| Biological process | Purine biosynthesis |
Function
Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.