DPM1 — Dolichyl-phosphate mannosyltransferase subunit 1, catalytic
DPM1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
DPM1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Innate lymphoid cells | ER-Golgi Trafficking Protein processing & ER | ATP2B1, ATP6V1D, CAPZA2, CGGBP1, CNOT4, COPS5, CRIPT, CSTB +15 more | View in SCUBA |
| Macrophages | Ubiquitin-Proteasome System Housekeeping | ACTR10, ADSS2, ATXN10, CAND1, CYRIB, DKC1, EIF4E, HSPA4 +18 more | View in SCUBA |
About the gene
| Synonyms | CDGIE, MPDS |
|---|---|
| Chromosome | 20: 50934867-50959140 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Glycosyltransferase, Transferase |
Function
Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins; catalytic subunit of the dolichol-phosphate mannose (DPM) synthase complex
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.