Ubiquitin-Proteasome System
Gene co-expression module in Macrophages
| Category | Housekeeping |
|---|---|
| Genes | 27 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 10 of 27 genes have a known function matching the annotation |
Why this annotation
Hub genes include DPM1 (dolichol-phosphate mannose synthase, required for GPI anchor and N-glycosylation), UBE2N (ubiquitin-conjugating enzyme E2N, K63-linked ubiquitination), HSPA4 (HSP70 family chaperone), PSMD1 and PSME3IP1 (proteasome 26S regulatory subunit and proteasome activator-related), UBA2 (SUMO E1 activating enzyme subunit). Additional members include EIF4E (cap-dependent translation), PRPF4 (spliceosome U4/U6 snRNP), DKC1 (dyskerin, ribosome biogenesis and telomerase), YWHAQ (14-3-3 theta, signaling scaffold), CAND1 (cullin-RING ligase regulator). The module centers on ubiquitin-proteasome system and protein homeostasis with contributions from translation and splicing. Mild prolif_mac enrichment for PRPF4, YWHAQ, DKC1 is consistent with higher proteostasis demand in proliferating cells.
Genes
ACTR10, ADSS2, ATXN10, CAND1, CYRIB, DKC1, DPM1, EIF4E, HSPA4, IFNGR1, MARCHF5, MBD2, NAA50, NIPA2, PATL1, PMPCB, PRPF4, PSMD1, PSME3IP1, RAP1A, SRP54, UBA2, UBE2N, USP14, XPNPEP1, XRN2, YWHAQ
Most correlated modules
- mRNA Splicing Processing · correlation 0.95
- RAS-MAPK Signaling · correlation 0.95
- RNA Splicing Regulation · correlation 0.95
- Endolysosomal Trafficking · correlation 0.95
- Actin Cytoskeleton Organization · correlation 0.94
- RNA Processing & Repair · correlation 0.94
- Protein Biogenesis · correlation 0.93
- Central Carbon Metabolism · correlation 0.93
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.