T Cell Exhaustion
Gene co-expression module in Gamma-delta T cells
| Category | Exhaustion |
|---|---|
| Genes | 29 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 29 genes have a known function matching the annotation |
Why this annotation
Top hub LAG3 is a canonical T cell exhaustion/inhibitory receptor and co-inhibitory checkpoint molecule. STIM1 (calcium entry for NFAT signaling, linked to T cell exhaustion), RELA (NF-kB p65, regulates exhaustion-associated genes), YTHDF2 (m6A reader, regulates mRNA of exhaustion TFs), RB1CC1 (autophagy regulator linked to T cell persistence), and SREBF2 (lipid metabolism dysregulation in exhaustion) support an exhaustion-associated state. ACADVL and ACSS1 indicate altered fatty acid metabolism typical of exhausted T cells. The module coherence is moderate, suggesting some admixture of metabolic regulation, but LAG3-centered exhaustion is the dominant theme.
Genes
ACADVL, ACSS1, ADSS2, B4GALT3, CDK11A, CHP1, CNOT2, CNOT8, CRELD2, CRTC2, FYTTD1, GNG2, IGFLR1, KDELR2, LAG3, LRRFIP1, MAML1, NISCH, OSBPL8, PRDM4, RB1CC1, RELA, RIC8A, SH2D2A, SREBF2, STIM1, TRPC4AP, UAP1, YTHDF2
Most correlated modules
- Innate Stress Signaling · correlation 0.82
- Chromatin Epigenetic Regulation · correlation 0.82
- mRNA Decay Regulation · correlation 0.81
- ER Protein Translocation · correlation 0.80
- Hypoxia Stress Response · correlation 0.80
- mRNA Splicing Processing · correlation 0.80
- T cell Identity Signaling · correlation 0.79
- Osmotic Stress Response · correlation 0.77
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.