CYRIB — CYFIP related Rac1 interactor B
CYRIB belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CYRIB's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Innate lymphoid cells | Mitochondrial Organization Mitochondrial & OxPhos | ARL5A, ATP5MJ, ATP5MK, BBLN, C18orf32, CIAO2B, EEF1G, FAM174C +21 more | View in SCUBA |
| Macrophages | Ubiquitin-Proteasome System Housekeeping | ACTR10, ADSS2, ATXN10, CAND1, DKC1, DPM1, EIF4E, HSPA4 +18 more | View in SCUBA |
| Natural Killer cells | Interferon NK Activation Inflammation | IFITM1, KLRK1, NHERF1, PLAAT4, RNASEK, SEPTIN9, TLE5, UBE2V1 | View in SCUBA |
| Neutrophils | Ubiquitin Regulatory Signaling Housekeeping | ARID4B, FBXW7, GRB2, QKI, RAB1A, SIK3, STK10, USP9X |
About the gene
| Synonyms | BM-009, CYRI, CYRI-B, FAM49B |
|---|---|
| Chromosome | 8: 129839593-130017504 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
Function
Negatively regulates RAC1 signaling and RAC1-driven cytoskeletal remodeling. Regulates chemotaxis, cell migration and epithelial polarization by controlling the polarity, plasticity, duration and extent of protrusions. Limits Rac1 mediated activation of the Scar/WAVE complex, focuses protrusion signals and regulates pseudopod complexity by inhibiting Scar/WAVE- induced actin polymerization. Protects against Salmonella bacterial infection. Attenuates processes such as macropinocytosis, phagocytosis and cell migration and restrict sopE- mediated bacterial entry. Also restricts infection mediated by Mycobacterium tuberculosis and Listeria monocytogenes (By similarity). Involved in the regulation of mitochondrial dynamics and oxidative stress.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.