AGTPBP1 — ATP/GTP binding carboxypeptidase 1
AGTPBP1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
AGTPBP1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | TGF-β Migration Program migration & adhesion | AHNAK, CAPN2, CYTH1, FLNA, RAP1GAP2, RASA3, SORL1, SYNE1 +2 more | |
| Mucosal-associated invariant T cell | Cytoskeletal Migration migration & adhesion | AHNAK, ATP2B4, DIAPH1, FLNA, IQSEC1, ITCH, ITGA4, OGDH +8 more |
About the gene
| Synonyms | CCP1, KIAA1035, Nna1 |
|---|---|
| Chromosome | 9: 85546539-85742029 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Carboxypeptidase, Hydrolase, Metalloprotease, Protease |
Function
Metallocarboxypeptidase that mediates protein deglutamylation of tubulin and non-tubulin target proteins. Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of alpha- and beta- tubulin. Specifically cleaves tubulin long-side-chains, while it is not able to remove the branching point glutamate. Also catalyzes the removal of polyglutamate residues from the carboxy-terminus of alpha-tubulin as well as non-tubulin proteins such as MYLK. Involved in KLF4 deglutamylation which promotes KLF4 proteasome-mediated degradation, thereby negatively regulating cell pluripotency maintenance and embryogenesis.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.