RASA3 — RAS p21 protein activator 3
RASA3 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RASA3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Naive T quiescence T cell development | CCR7, CD55, CRIP2, CSGALNACT1, ITGA6, KLF2, KLF3, NOSIP +6 more | View in SCUBA |
| Gamma-delta T cells | TGF-β Migration Program migration & adhesion | AGTPBP1, AHNAK, CAPN2, CYTH1, FLNA, RAP1GAP2, SORL1, SYNE1 +2 more | |
| Mucosal-associated invariant T cell | Cytoskeletal Migration migration & adhesion | AGTPBP1, AHNAK, ATP2B4, DIAPH1, FLNA, IQSEC1, ITCH, ITGA4 +8 more | |
| Natural Killer cells | NK Activation Signaling activation | CEP78, PLSCR3, PSAP, SLC44A2, SUN2, ZAP70, ZYX | View in SCUBA |
About the gene
| Synonyms | GAP1IP4BP, GAPIII |
|---|---|
| Chromosome | 13: 113977783-114132623 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins, RAS pathway related proteins |
| Molecular function | GTPase activation |
Function
Inhibitory regulator of the Ras-cyclic AMP pathway. Binds inositol tetrakisphosphate (IP4) with high affinity. Might be a specific IP4 receptor
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.