Cytoskeletal Migration
Gene co-expression module in Mucosal-associated invariant T cell
| Category | migration & adhesion |
|---|---|
| Genes | 17 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 11 of 17 genes have a known function matching the annotation |
Why this annotation
Hub genes SYNE1/SYNE2 (nesprins), SPTBN1 (spectrin beta), FLNA (filamin A), PLEC (plectin), DIAPH1 (formin), AHNAK (scaffold), and ITGA4 (integrin alpha-4) define a cytoskeletal structural and cell migration/adhesion program. RASA3 and IQSEC1 regulate small GTPases relevant to actin dynamics. TGFBR3 and ATP2B4 may modulate cytoskeletal calcium signaling. Strong coherence supports a unified cytoskeletal/migratory program in MAIT cells.
Genes
AGTPBP1, AHNAK, ATP2B4, DIAPH1, FLNA, IQSEC1, ITCH, ITGA4, OGDH, PDE3B, PLEC, RASA3, SORL1, SPTBN1, SYNE1, SYNE2, TGFBR3
Most correlated modules
- PI3K-Calcineurin Signaling · correlation 0.73
- Chromatin Regulation · correlation 0.72
- SWI/SNF Chromatin Remodeling · correlation 0.72
- Cytoskeletal Migration · correlation 0.71
- Lymphocyte Migration · correlation 0.69
- Cellular Maintenance · correlation 0.69
- T cell Homeostasis · correlation 0.69
- Lymphocyte Migration · correlation 0.68
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.