TGF-β Migration Program
Gene co-expression module in Gamma-delta T cells
| Category | migration & adhesion |
|---|---|
| Genes | 11 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 9 of 11 genes have a known function matching the annotation |
Why this annotation
TGFBR3 (TGF-β receptor III/betaglycan) is the top hub, anchoring a TGF-β signaling context. AHNAK is a scaffold protein involved in TGF-β-induced cell migration and membrane-cytoskeleton coupling. FLNA (filamin A) and CAPN2 (calpain-2) mediate cytoskeletal remodeling during migration. CYTH1 (cytohesin-1) activates integrins and promotes cell migration. SYNE1 (nesprin-1) links the nucleus to the cytoskeleton. RASA3 and RAP1GAP2 regulate Rap1/Ras GTPases controlling adhesion dynamics. TNIK participates in Wnt/cytoskeletal signaling. As a topological neighbor to M158 (integrin/adhesion), this module extends into TGF-β-regulated cytoskeletal and migratory programs.
Genes
AGTPBP1, AHNAK, CAPN2, CYTH1, FLNA, RAP1GAP2, RASA3, SORL1, SYNE1, TGFBR3, TNIK
Most correlated modules
- γδ T Cell Identity · correlation 0.90
- TCR Activation Signaling · correlation 0.89
- Cytotoxic Effector Program · correlation 0.85
- TCR-Cytokine Signaling · correlation 0.84
- Butyrophilin gd Activation · correlation 0.84
- TCR Proximal Signaling · correlation 0.80
- Naive T cell quiescence · correlation 0.80
- Lymphocyte Tissue Egress · correlation 0.77
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.