ANKZF1 — Ankyrin repeat and zinc finger peptidyl tRNA hydrolase 1
ANKZF1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ANKZF1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | EOMES Effector Program T cell maturation | AGK, ATG16L2, C6orf120, CARD8, CBX1, CDK5RAP3, CENPT, COPB1 +25 more | |
| Mucosal-associated invariant T cell | IL-12 Cytotoxic Effector cytotoxicity | ATP8B2, CD84, CTSH, DIP2A, HERC2, IL12RB1, LPCAT4, MBOAT1 +7 more |
About the gene
| Synonyms | FLJ10415, Vms1, ZNF744 |
|---|---|
| Chromosome | 2: 219229783-219236679 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Endonuclease, Hydrolase, Nuclease |
Function
Endonuclease that cleaves polypeptidyl-tRNAs downstream of the ribosome-associated quality control (RQC) pathway to release incompletely synthesized polypeptides for degradation. The RQC pathway disassembles aberrantly stalled translation complexes to recycle or degrade the constituent parts. ANKZF1 acts downstream disassembly of stalled ribosomes and specifically cleaves off the terminal 3'-CCA nucleotides universal to all tRNAs from polypeptidyl-tRNAs, releasing (1) ubiquitinated polypeptides from 60S ribosomal subunit for degradation and (2) cleaved tRNAs. ANKZF1-cleaved tRNAs are then repaired and recycled by ELAC1 and TRNT1. Also plays a role in the cellular response to hydrogen peroxide and in the maintenance of mitochondrial integrity under conditions of cellular stress.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.