DIP2A — Disco interacting protein 2 homolog A
DIP2A belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
DIP2A's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | RNA & Chromatin Regulation RNA processing | ATRX, DCP2, HNRNPLL, KDM5B, NCOR1, OGDH, RIOK3, SAMD9 +7 more | View in SCUBA |
| Macrophages | DNA Damage Repair Stress | ABCC5, ADAM28, AKAP9, AKNA, ATM, ATP10D, BAZ2A, CHD9 +27 more | View in SCUBA |
| Mucosal-associated invariant T cell | IL-12 Cytotoxic Effector cytotoxicity | ANKZF1, ATP8B2, CD84, CTSH, HERC2, IL12RB1, LPCAT4, MBOAT1 +7 more | |
| Natural Killer cells | Cytoskeletal Remodeling Cytoskeleton & motility | ADD3, ARHGAP25, ARHGEF3, C1orf21, CAPN2, CYTH1, DGKZ, GBP5 +4 more | View in SCUBA |
About the gene
| Synonyms | C21orf106, Dip2, KIAA0184 |
|---|---|
| Chromosome | 21: 46458891-46570015 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Enzymes, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Developmental protein, Ligase |
| Biological process | Neurogenesis |
Function
Catalyzes the de novo synthesis of acetyl-CoA in vitro (By similarity). Promotes acetylation of CTTN, possibly by providing the acetyl donor, ensuring correct dendritic spine morphology and synaptic transmission (By similarity). Binds to follistatin-related protein FSTL1 and may act as a cell surface receptor for FSTL1, contributing to AKT activation and subsequent FSTL1-induced survival and function of endothelial cells and cardiac myocytes
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.