IL12RB1 — Interleukin 12 receptor subunit beta 1
IL12RB1 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
IL12RB1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Interferon response Anti-viral | ACTN4, CAPZA1, CHMP4A, CHMP5, EFHD2, LSP1, PARP14, PIN1 +7 more | View in SCUBA |
| Innate lymphoid cells | IFN-driven ILC1 Activation Inflammation | AFF3, AGPAT5, AKIRIN2, APMAP, ARF6, ARHGEF1, DNAJC1, DYNLT3 +21 more | View in SCUBA |
| Mucosal-associated invariant T cell | IL-12 Cytotoxic Effector cytotoxicity | ANKZF1, ATP8B2, CD84, CTSH, DIP2A, HERC2, LPCAT4, MBOAT1 +7 more |
About the gene
| Synonyms | CD212, IL12RB |
|---|---|
| Chromosome | 19: 18058995-18098944 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | CD markers, Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Receptor |
Function
Functions as an interleukin receptor which binds interleukin- 12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. Also associates with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.