EOMES Effector Program
Gene co-expression module in Gamma-delta T cells
| Category | T cell maturation |
|---|---|
| Genes | 34 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 34 genes have a known function matching the annotation |
Why this annotation
EOMES (Eomesodermin) is a strong-membership hub gene and master transcription factor for effector/mature gd T, NK, and CD8 T cell identity — directly driving cytotoxic and tissue-resident programs. PILRB (paired immunoglobulin-like receptor B, NK/myeloid activation receptor expressed on some T cells), IL12RB2 (IL-12 receptor, effector T cell cytokine signaling), CARD8 (inflammasome component), UBA7 (ISGylation pathway), ATG16L2 (autophagy), and NUP62 (nuclear transport) support a mature effector T cell regulatory program. CBX1 and PAGR1 contribute chromatin-level control of differentiation. The module reflects EOMES-driven T cell maturation/effector programming in gd T cells.
Genes
AGK, ANKZF1, ATG16L2, C6orf120, CARD8, CBX1, CDK5RAP3, CENPT, COPB1, CYTH3, EOMES, ERGIC1, FCMR, HARS2, IL12RB2, LSR, NEK7, NUP62, OGFR, PAGR1, PGGHG, PHF11, PILRB, SH3BP2, SHKBP1, SLC39A10, TMEM175, TRIM69, TRNT1, UBA7, UTP3, VRK3, ZBTB25, ZNF830
Most correlated modules
- T cell cAMP Signaling · correlation 0.86
- SR Kinase & RNA · correlation 0.81
- Antiviral ISG Response · correlation 0.74
- gd T Cell Identity · correlation 0.70
- ER Glycoprotein Quality Control · correlation 0.70
- Mitochondrial Biogenesis · correlation 0.65
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.