SCUBA

CTSH — Cathepsin H

CTSH belongs to a gene co-expression module in 9 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

CTSH's module in each cell type

Cell typeModuleShares the module with
CD19⁺ B cellsB cell activation
BCR/AP1/NFKb pathway
ADGRG5, BCAR3, CD86, CLIP2, CNOT2, FAS, GABARAPL2, GPR137B +7 moreView in SCUBA
CD4⁺ T cellsIntegrin Adhesion Migration
migration & adhesion
ARAP2, ATF7IP, C4orf3, CLEC2B, COTL1, DEK, DIAPH1, EML4 +11 moreView in SCUBA
FibroblastsFRC function
Immune interaction
ADRA2A, ANKRD29, CCL19, CCL21, GP1BA, IL3RA, KCNK13, NPB +3 moreView in SCUBA
Gamma-delta T cellsγδT17 Effector
Inflammation
AQP3, CCR6, CEBPD, COLQ, CTSA, EDEM2, GCHFR, IL23R +10 more
Innate lymphoid cellsILC Survival Residency
Gut residency
ARID4B, BAZ1A, BCL2A1, CD44, CSF2, CXCL8, DUSP4, ENTPD1 +25 moreView in SCUBA
Lymphatic endothelialECM Remodeling TGFb
migration & adhesion
CCDC80, CCND1, CHRDL1, CRIP1, ECSCR, HS3ST1, IARS2, LAMB2 +8 moreView in SCUBA
MacrophagesIFN-gamma Response
Inflammatory
ANKRD22, APOL2, ATF5, ATP13A1, CD274, CD300LF, CD40, CD48 +21 moreView in SCUBA
Mucosal-associated invariant T cellIL-12 Cytotoxic Effector
cytotoxicity
ANKZF1, ATP8B2, CD84, DIP2A, HERC2, IL12RB1, LPCAT4, MBOAT1 +7 more
PericytesBMP-SMAD Signaling
Developmental
ETS2, EXOC3L2, IL3RA, ITM2A, MCF2L, NDST1, PDE2A, SCARB1 +3 moreView in SCUBA

About the gene

SynonymsACC-4, ACC-5, ACC4, ACC5, CPSB
Chromosome15: 78921058-78949574
Predicted locationIntracellular
Essential geneNo
Protein classCancer-related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins
Molecular functionHydrolase, Protease, Thiol protease

Function

Important for the overall degradation of proteins in lysosomes

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.