IL-12 Cytotoxic Effector
Gene co-expression module in Mucosal-associated invariant T cell
| Category | cytotoxicity |
|---|---|
| Genes | 16 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 16 genes have a known function matching the annotation |
Why this annotation
IL12RB1 (IL-12 receptor beta-1, essential for MAIT cell cytokine-driven activation and IFN-gamma production), UNC13D (Munc13-4, critical for cytotoxic granule priming and degranulation), CD84 (SLAM family receptor, co-stimulatory in NK/NKT/MAIT cells), CTSH (cathepsin H, lysosomal protease active in cytotoxic cells), NR1D1 (Rev-erb alpha, circadian/nuclear receptor), and TSPAN15 collectively point to an IL-12-driven cytotoxic effector program in MAIT cells. IL12RB1 + UNC13D is a strong cytotoxic MAIT effector signature. CTSH supports lysosomal/degranulation activity. Neighboring modules (M70, M67) contain circadian and chromatin regulators; NR1D1 here may reflect circadian modulation of cytotoxic readiness.
Genes
ANKZF1, ATP8B2, CD84, CTSH, DIP2A, HERC2, IL12RB1, LPCAT4, MBOAT1, NR1D1, PNISR, PRR12, SLC35E2B, TMEM273, TSPAN15, UNC13D
Most correlated modules
- T cell Activation Signaling · correlation 0.88
- TCR Signaling Identity · correlation 0.84
- T cell Homeostasis · correlation 0.80
- PI3K-Calcineurin Signaling · correlation 0.79
- Chromatin Complex Regulation · correlation 0.76
- T cell Transcriptional Identity · correlation 0.76
- Chromatin Maintenance State · correlation 0.75
- Cytoskeletal Remodeling Migration · correlation 0.73
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.