COPB1 — COPI coat complex subunit beta 1
COPB1 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
COPB1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | EOMES Effector Program T cell maturation | AGK, ANKZF1, ATG16L2, C6orf120, CARD8, CBX1, CDK5RAP3, CENPT +25 more | |
| Goblet cells | Protein trafficking & glycosylation Mucus production & secretion | COPA, COPB2, COPG1, EDEM3, FAM114A1, GALNT3, GALNT7, TM9SF2 +1 more | View in SCUBA |
| Innate lymphoid cells | RNA Chromatin Regulation RNA processing & translation | ACADM, AURKAIP1, BUD23, CBX3, CMC2, DNAJA2, DYNC1LI1, G3BP1 +19 more | View in SCUBA |
| Macrophages | ER Membrane Homeostasis Housekeeping | ATP6V1A, BNIP2, CANX, CAPZA1, CD164, CMTM6, EXOC5, GFM1 +18 more | View in SCUBA |
About the gene
| Synonyms | COPB |
|---|---|
| Chromosome | 11: 14443440-14500027 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Disease related genes, Essential proteins, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins |
| Biological process | ER-Golgi transport, Host-virus interaction, Protein transport, Transport |
Function
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. Plays a functional role in facilitating the transport of kappa-type opioid receptor mRNAs into axons and enhances translation of these proteins. Required for limiting lipid storage in lipid droplets. Involved in lipid homeostasis by regulating the presence of perilipin family members PLIN2 and PLIN3 at the lipid droplet surface and promoting the association of adipocyte surface triglyceride lipase (PNPLA2) with the lipid droplet to mediate lipolysis (By similarity). Involved in the Golgi disassembly and reassembly processes during cell cycle. Involved in autophagy by playing a role in early endosome function. Plays a role in organellar compartmentalization of secretory compartments including endoplasmic reticulum (ER)-Golgi intermediate compartment (ERGIC), Golgi, trans-Golgi network (TGN) and recycling endosomes, and in biosynthetic transport of CAV1. Promotes degradation of Nef cellular targets CD4 and MHC class I antigens by facilitating their trafficking to degradative compartments.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.