CBX1 — Chromobox 1
CBX1 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CBX1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | EOMES Effector Program T cell maturation | AGK, ANKZF1, ATG16L2, C6orf120, CARD8, CDK5RAP3, CENPT, COPB1 +25 more | |
| Goblet cells | Chromatin RNA Regulation chromatin regulation & transcription | ANP32A, HDAC2, HNRNPA0, HNRNPM, KHDRBS1, NONO, RBMX, RCN2 +1 more | View in SCUBA |
| Macrophages | DNA Replication Metabolism Cell cycle | AGPAT5, DCK, FADS1, HACD3, HADH, ICMT, IDH2, MTHFD1 +11 more | View in SCUBA |
About the gene
| Synonyms | CBX, HP1-BETA, HP1Hs-beta, M31, MOD1 |
|---|---|
| Chromosome | 17: 48070052-48101478 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
Function
Component of heterochromatin. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.