APC — APC regulator of WNT signaling pathway
APC belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
APC's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Long-gene transcript bias Technical artifact | CNGA1, CYP2C9, KLHL24, MAP3K2, PALS1, PLA2G4C, TRHDE | View in SCUBA |
| Lymphatic endothelial | Endosomal Vesicle Trafficking Housekeeping | ADAM10, APP, ATP9A, GLG1, MTR, NCOA3, PCNX4, PDCD6IP +5 more | View in SCUBA |
| Mucosal-associated invariant T cell | Immune Synapse Signaling TCR Signaling | ARHGAP26, ASXL2, CD46, CPSF2, DOCK8, EEA1, EIF4G3, EPB41 +21 more |
About the gene
| Synonyms | DP2, DP2.5, DP3, PPP1R46 |
|---|---|
| Chromosome | 5: 112707498-112846239 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins |
| Biological process | Wnt signaling pathway |
Function
Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)- induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Associates with both microtubules and actin filaments, components of the cytoskeleton. Plays a role in mediating the organization of F- actin into ordered bundles. Functions downstream of Rho GTPases and DIAPH1 to selectively stabilize microtubules (By similarity). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.