Endosomal Vesicle Trafficking
Gene co-expression module in Lymphatic endothelial
| Category | Housekeeping |
|---|---|
| Genes | 14 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 14 genes have a known function matching the annotation |
Why this annotation
Hub genes PDCD6IP (ALIX, MVB/exosome sorting), GLG1 (Golgi vesicle trafficking), ATP9A (endosomal lipid flippase P4-ATPase), USP33 (deubiquitinase regulating vesicle trafficking/COPI), and APP (vesicle-associated transmembrane protein) collectively define an endosomal/vesicle trafficking program. ADAM10 contributes ectodomain shedding at endosomes. SERINC5 and APC add membrane lipid and cytoskeletal-membrane interface biology. All genes show uniform expression with no lineage contamination signal.
Genes
ADAM10, APC, APP, ATP9A, GLG1, MTR, NCOA3, PCNX4, PDCD6IP, PHACTR4, PHF14, SERINC5, SKAP2, USP33
Most correlated modules
- Chromatin Remodeling · correlation 0.95
- Actin Cytoskeletal Scaffold · correlation 0.91
- Hypoxia Response · correlation 0.90
- Lymphatic Valve Development · correlation 0.90
- Lymphatic EC Identity · correlation 0.89
- Actomyosin Contractility · correlation 0.89
- Cilia Centrosome Program · correlation 0.89
- Lipid Metabolic Regulation · correlation 0.88
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.