Immune Synapse Signaling
Gene co-expression module in Mucosal-associated invariant T cell
| Category | TCR Signaling |
|---|---|
| Genes | 30 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 30 genes have a known function matching the annotation |
Why this annotation
DOCK8 is the top hub gene — a Cdc42 GEF critical for T cell immune synapse formation, migration, and survival of innate-like lymphocytes. STIM1 is essential for store-operated calcium entry (SOCE) and T cell activation. CD46 is a complement regulator that also acts as a co-stimulatory molecule regulating T cell effector function. ARHGAP26 is a Rho GAP regulating cytoskeletal dynamics. APC coordinates microtubule organization at the immune synapse. TRIP12 is an E3 ubiquitin ligase. RAP1GDS1 (SmgGDS) activates Rap1/RhoA GTPases important for T cell adhesion and migration. NSD1 is a histone methyltransferase. NPAT is involved in S-phase histone transcription. SLF2 participates in DNA damage response. The dominant theme integrating DOCK8, STIM1, CD46, APC, RAP1GDS1, and ARHGAP26 is immune synapse formation and T cell activation signaling, consistent with MAIT effector function. As a neighbor of M78 and M80, this module extends the cytoskeletal/regulatory neighborhood.
Genes
APC, ARHGAP26, ASXL2, CD46, CPSF2, DOCK8, EEA1, EIF4G3, EPB41, GPCPD1, MICAL2, MORC3, MTR, NPAT, NSD1, PARP4, PKN2, R3HDM1, RALGAPA2, RAP1GDS1, RERE, SCLT1, SLF2, STIM1, SUCLG2, TBCK, TRIP12, UBR2, ZNF217, ZNF33A
Most correlated modules
- Lymphocyte Migration · correlation 0.83
- Calcineurin-NFAT Signaling · correlation 0.81
- T cell Homeostasis · correlation 0.80
- Integrin Actin Adhesion · correlation 0.79
- Chromatin Remodeling · correlation 0.76
- Cytoskeletal Migration · correlation 0.75
- Nuclear regulatory housekeeping · correlation 0.75
- TCR Activation Signaling · correlation 0.72
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.