Mitochondrial Biogenesis
Gene co-expression module in Gamma-delta T cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 16 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 16 genes have a known function matching the annotation |
Why this annotation
COQ7 (coenzyme Q biosynthesis, mitochondrial) and LETM2 (mitochondrial inner membrane protein) are top strong-membership hubs pointing to mitochondrial function. STK16 (Golgi-associated serine/threonine kinase), EPS8 (actin remodeling/receptor signaling), ARRDC3 (arrestin-domain receptor internalization), HELQ (DNA helicase/repair), PCF11 (cleavage/polyadenylation factor), PPP1R10 (phosphatase regulatory subunit/chromatin), and WSB1 (ubiquitin E3 adaptor) represent diverse housekeeping functions. The module has moderate coherence and low expression, suggesting a loosely co-regulated housekeeping program with a mitochondrial biosynthesis thread. COQ7/LETM2 provide the strongest coherent signal.
Genes
ARFIP1, ARRDC3, COG2, COQ7, DXO, EPM2AIP1, EPS8, HELQ, LETM2, LRRC23, PCF11, PHF20L1, PPP1R10, STK16, WDSUB1, WSB1
Most correlated modules
- mRNA Splicing Regulation · correlation 0.76
- Centrosome Organization · correlation 0.76
- T Cell Phosphatase Signaling · correlation 0.73
- T cell cAMP Signaling · correlation 0.69
- EOMES Effector Program · correlation 0.65
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.