BMP1 — Bone morphogenetic protein 1
BMP1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
BMP1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | IL-13/STAT6 Signaling Inflammation | ABLIM1, ARL2BP, ASRGL1, ATP8B1, BMPR2, CLIP1, CMIP, EHBP1L1 +18 more | View in SCUBA |
| Fibroblasts | Activated Myofibroblast State Wound healing | BGN, CPXM1, CTHRC1, EGFL6, FAP, KIAA0930, MASP1, OLFML2B +7 more | View in SCUBA |
About the gene
| Synonyms | BMP-1, PCOLC |
|---|---|
| Chromosome | 8: 22165140-22212326 |
| Predicted location | Secreted |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted secreted proteins |
| Molecular function | Cytokine, Developmental protein, Growth factor, Hydrolase, Metalloprotease, Protease |
| Biological process | Chondrogenesis, Differentiation, Osteogenesis |
Function
Metalloprotease that plays key roles in regulating the formation of the extracellular matrix (ECM) via processing of various precursor proteins into mature functional enzymes or structural proteins. Thereby participates in several developmental and physiological processes such as cartilage and bone formation, muscle growth and homeostasis, wound healing and tissue repair. Roles in ECM formation include cleavage of the C-terminal propeptides from procollagens such as procollagen I, II and III or the proteolytic activation of the enzyme lysyl oxidase LOX, necessary to formation of covalent cross- links in collagen and elastic fibers. Additional substrates include matricellular thrombospondin-1/THBS1 whose cleavage leads to cell adhesion disruption and TGF-beta activation. Plays an important role in bone repair by acting as a coactivator of BMP7
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.