MASP1 — MBL associated serine protease 1
MASP1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MASP1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | Activated Myofibroblast State Wound healing | BGN, BMP1, CPXM1, CTHRC1, EGFL6, FAP, KIAA0930, OLFML2B +7 more | View in SCUBA |
| Pericytes | Pericyte ECM Secretion ECM production | ATP1A2, CPM, CSRP2, DACH1, EFEMP1, FRZB, GULP1, NDUFAF4 +3 more | View in SCUBA |
About the gene
| Synonyms | CRARF, MAP-1, Map44, MASP, MASP-3, PRSS5 |
|---|---|
| Chromosome | 3: 187217282-187291980 |
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins |
| Molecular function | Hydrolase, Protease, Serine protease |
| Biological process | Complement activation lectin pathway, Immunity, Innate immunity |
Function
Functions in the lectin pathway of complement, which performs a key role in innate immunity by recognizing pathogens through patterns of sugar moieties and neutralizing them. The lectin pathway is triggered upon binding of mannan-binding lectin (MBL) and ficolins to sugar moieties which leads to activation of the associated proteases MASP1 and MASP2. Functions as an endopeptidase and may activate MASP2 or C2 or directly activate C3 the key component of complement reaction. Isoform 2 may have an inhibitory effect on the activation of the lectin pathway of complement or may cleave IGFBP5. Also plays a role in development.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.