IL-13/STAT6 Signaling
Gene co-expression module in Endothelial
| Category | Inflammation |
|---|---|
| Genes | 27 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 27 genes have a known function matching the annotation |
Why this annotation
The co-expression of IL13RA1 (IL-13 receptor alpha 1) and STAT6 (the canonical transcription factor downstream of IL-4 and IL-13) strongly identifies this as a type 2 cytokine (IL-13/IL-4) signaling module. This is biologically coherent: IL-13 is elevated in IBD, particularly UC, and endothelial cells express IL13RA1 and activate STAT6. BMPR2 (BMP receptor 2) is a key vascular endothelial receptor. ENTPD1 (CD39) is an ectonucleotidase expressed on endothelial cells with anti-inflammatory purinergic roles. MYOF (myoferlin) mediates membrane fusion and VEGFR2 recycling in endothelial cells. LAMA5 and FBN1 are ECM components. TCN2 (transcobalamin II) is expressed by endothelial cells. The module is upregulated in both UC and CD inflammation, consistent with type 2 inflammatory signaling. Neighbor context: IL33 in M52 is an upstream driver of type 2 responses, supporting this IL-13/STAT6 module as a downstream effector program.
Genes
ABLIM1, ARL2BP, ASRGL1, ATP8B1, BMP1, BMPR2, CLIP1, CMIP, EHBP1L1, ELMO1, ENTPD1, EVL, FAM124A, FBN1, FIS1, HIP1, IL13RA1, LAMA5, MAPK11, MYOF, NUDCD1, PDLIM5, PPP1CB, STAT6, TCN2, TMEM219, ZDHHC2
Most correlated modules
- Oxidative Stress Response · correlation 0.82
- ER-Golgi Trafficking · correlation 0.81
- TRAIL-mediated Apoptosis · correlation 0.80
- IL33 Alarmin Signaling · correlation 0.64
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.