PI3K-Calcineurin Signaling
Gene co-expression module in Mucosal-associated invariant T cell
| Category | TCR Signaling |
|---|---|
| Genes | 11 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 11 genes have a known function matching the annotation |
Why this annotation
Hub genes PIK3CD (PI3K-delta, critical for T cell survival/activation), PTPN18 (phosphatase regulating TCR signaling), RAP2B (Ras-family GTPase downstream of TCR), CABIN1 (calcineurin inhibitor modulating NFAT), and LATS2 (Hippo kinase) collectively point to a T cell intracellular signaling regulation program. POM121C and NUP210 are nuclear pore components possibly involved in signaling-driven nuclear transport. ACLY links to metabolic reprogramming downstream of PI3K. The module is coherent but mixed; the dominant theme is PI3K/calcineurin/phosphatase-mediated T cell signaling homeostasis.
Genes
ACLY, BCL9L, CABIN1, CDK11A, LATS2, NBPF19, NUP210, PIK3CD, POM121C, PTPN18, RAP2B
Most correlated modules
- T cell Activation Signaling · correlation 0.84
- IL-12 Cytotoxic Effector · correlation 0.79
- Cytoskeletal Organization · correlation 0.78
- T cell Transcriptional Identity · correlation 0.77
- Cytoskeletal Remodeling Migration · correlation 0.76
- mRNA 3' Processing · correlation 0.75
- Cytoskeletal Migration · correlation 0.73
- SWI/SNF Chromatin Remodeling · correlation 0.72
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.