CCM2 — CCM2 scaffold protein
CCM2 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CCM2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | T-cell costimulation TCR/AP1/NFKb pathway | ASH1L, BOD1L1, CCR4, CD28, CREBRF, DDX27, ERBIN, ICOS +10 more | View in SCUBA |
| Mucosal-associated invariant T cell | Cytotoxic Effector cytotoxicity | ANXA4, CD320, CST7, DYNLRB1, GZMM, LIMD2, MCUB, MGMT +10 more |
About the gene
| Synonyms | C7orf22, MGC4607, OSM |
|---|---|
| Chromosome | 7: 44999475-45076469 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins |
| Molecular function | Developmental protein |
Function
Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions (By similarity). May function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3-dependent p38 activation induced by hyperosmotic shock (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.