DYNLRB1 — Dynein light chain roadblock-type 1

DYNLRB1 belongs to a gene co-expression module in 10 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

DYNLRB1's module in each cell type

Cell type	Module	Shares the module with
CD4⁺ T cells	Oxidative Phosphorylation Mitochondrial & OxPhos	ATP5F1E, BLOC1S1, COX5B, COX6A1, COX6C, COX8A, GMFG, SH3BGRL +6 more	View in SCUBA
CD8⁺ T cells	Stress-ISG Response Stress	CD53, DDIT4, DRAP1, LY6E, PAIP2, PLEKHF1, PSME1, SHISA5 +5 more	View in SCUBA
Fibroblasts	WAVE-RAC1 Actin Cytoskeletal	BRK1, C11orf58, C4orf3, CHCHD2, MRFAP1, PPIA, RAC1, SSR2 +1 more	View in SCUBA
Gamma-delta T cells	Protein Homeostasis Chaperones Housekeeping	ATXN10, GMFG, HIGD1A, NAA10, POLR2J, PPIA, PPIB, PRDX2 +6 more
Glial cells	Antioxidant Stress Response Stress	AP2S1, CSTB, HSBP1, MAGED2, NDUFB11, PLPP1, PPDPF, SELENOW +1 more	View in SCUBA
Innate lymphoid cells	RNA Splicing Processing RNA processing & translation	ATP5F1C, CHMP2A, CHMP4A, CYBA, DSTN, DYNC1I2, FKBP3, LSM3 +16 more	View in SCUBA
Lymphatic endothelial	Protein Quality Control Protein processing & ER	BCAP29, CD99, CDC42, GNG5, NDUFV2, PDCD6, PFDN5, SKP1 +1 more	View in SCUBA
Macrophages	Mixed Housekeeping Housekeeping	AP2M1, BAG1, CHMP4A, CISD2, COA6, CSNK2B, CYB5R3, DEGS1 +20 more	View in SCUBA
Mucosal-associated invariant T cell	Cytotoxic Effector cytotoxicity	ANXA4, CCM2, CD320, CST7, GZMM, LIMD2, MCUB, MGMT +10 more
Natural Killer cells	Cellular Homeostasis Metabolism	APRT, ATP5F1E, ATP6V0E1, CD63, OAZ1, PSMA7, SSR4, TMSB4X +1 more	View in SCUBA

About the gene

Synonyms	DNCL2A, DNLC2A, ROBLD1
Chromosome	20: 34516395-34540958
Predicted location	Intracellular
Essential gene	Yes
Protein class	Essential proteins, Plasma proteins, Predicted intracellular proteins
Molecular function	Motor protein
Biological process	Transport

Function

Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.