CST7 — Cystatin F
CST7 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CST7's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Proteasome translation Housekeeping | ADRM1, CD2BP2, CDV3, EHBP1L1, EIF3J, ENO1, HSBP1, MAPKAPK2 +5 more | View in SCUBA |
| CD8⁺ T cells | Effector-Memory CD8 T cell maturation | CD27, CD44, CMC1, CXCR3, DUSP2, EOMES, F2R, HLA-E +8 more | View in SCUBA |
| Gamma-delta T cells | Cytotoxic Effector Program cytotoxicity | APMAP, C16orf54, CTSW, EHD1, HLA-A, HLA-B, HLA-C, HLA-E +8 more | |
| Monocytes | BPI Antibacterial Response Antibacterial | ADGRG3, ANXA3, BPI, CMTM2, CYP4F3, LGALS12, MGAM, RGL4 +6 more | View in SCUBA |
| Mucosal-associated invariant T cell | Cytotoxic Effector cytotoxicity | ANXA4, CCM2, CD320, DYNLRB1, GZMM, LIMD2, MCUB, MGMT +10 more | |
| Neutrophils | Neutrophil Motility Cytoskeleton Migration & adhesion | CDKN2D, CNN2, COTL1, GLIPR1, GMFG, GNB2, GPSM3, JPT1 +9 more |
About the gene
| Chromosome | 20: 24949269-24959928 |
|---|---|
| Predicted location | Secreted |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted secreted proteins |
| Molecular function | Protease inhibitor, Thiol protease inhibitor |
Function
Inhibits papain and cathepsin L but with affinities lower than other cystatins. May play a role in immune regulation through inhibition of a unique target in the hematopoietic system
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.