Cytotoxic Effector
Gene co-expression module in Mucosal-associated invariant T cell
| Category | cytotoxicity |
|---|---|
| Genes | 19 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 19 genes have a known function matching the annotation |
Why this annotation
RASGRP2 (RasGRP2/CalDAG-GEFI, activates Rap1 to regulate integrin-mediated adhesion in T cells and is important for T cell activation), GZMM (granzyme M, serine protease in cytotoxic lymphocyte granules), CST7 (cystatin F, expressed in cytotoxic T and NK cells, inhibits cathepsins in granules), UCP2 (uncoupling protein 2, mitochondrial, expressed in activated immune cells), CCM2 (cerebral cavernous malformation 2, MAPK scaffold), LIMD2 (LIM domain protein, focal adhesion), SNRPD3 (spliceosome Sm protein), MGMT (O6-methylguanine-DNA methyltransferase, DNA repair), TSPO (translocator protein, outer mitochondrial membrane, steroidogenesis/immune regulation), NELL2 (neural EGFL-like 2, expressed in lymphocytes), TRAPPC6A (trafficking protein particle complex), TMEM203 (STING interactor?), MCUB (mitochondrial calcium uniporter beta subunit), DYNLRB1 (dynein light chain), ANXA4 (annexin A4), VKORC1 (vitamin K epoxide reductase), CD320 (transcobalamin receptor), TSTD1, POP5. The top hubs RASGRP2, GZMM, CST7 clearly define a cytotoxic/effector T cell program. Neighbor to M33 (NKG7+), confirming cytotoxic neighborhood.
Genes
ANXA4, CCM2, CD320, CST7, DYNLRB1, GZMM, LIMD2, MCUB, MGMT, NELL2, POP5, RASGRP2, SNRPD3, TMEM203, TRAPPC6A, TSPO, TSTD1, UCP2, VKORC1
Most correlated modules
- Cytotoxic Lymphocyte Program · correlation 0.90
- Leukocyte Housekeeping · correlation 0.86
- ER & Mitochondrial Assembly · correlation 0.84
- T cell Surface Signaling · correlation 0.81
- mRNA Export & Processing · correlation 0.81
- Mature Effector MAIT · correlation 0.79
- Mitochondrial Housekeeping · correlation 0.79
- T cell Homeostasis · correlation 0.79
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.