GZMM — Granzyme M
GZMM belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
GZMM's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | TCR Complex Activation TCR/AP1/NFKb pathway | ABHD17A, ACTR3, C1GALT1, CD2, CD3D, CD3E, CD3G, CD81 +14 more | View in SCUBA |
| Gamma-delta T cells | Effector IFN Response cytotoxicity | AGTRAP, ANXA1, B2M, CYBA, EMP3, FXYD5, IFITM1, IFITM2 +9 more | |
| Mucosal-associated invariant T cell | Cytotoxic Effector cytotoxicity | ANXA4, CCM2, CD320, CST7, DYNLRB1, LIMD2, MCUB, MGMT +10 more |
About the gene
| Synonyms | LMET1, MET1 |
|---|---|
| Chromosome | 19: 544034-549924 |
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins |
| Molecular function | Hydrolase, Protease, Serine protease |
| Biological process | Apoptosis, Cytolysis, Immunity, Innate immunity |
Function
Cleaves peptide substrates after methionine, leucine, and norleucine. Physiological substrates include EZR, alpha-tubulins and the apoptosis inhibitor BIRC5/Survivin. Promotes caspase activation and subsequent apoptosis of target cells.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.