Oxidative Phosphorylation
Gene co-expression module in Innate lymphoid cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 24 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 20 genes have a known function matching the annotation |
Why this annotation
This strong-coherence module contains several mitochondrial and OxPhos-related genes. Hub genes include DMAC1 (distal membrane arm assembly component, Complex I assembly), PTRHD1 (peptidyl-tRNA hydrolase domain), HDAC2 (histone deacetylase 2, chromatin), SNX17 (sorting nexin, endosomal trafficking), SPAG7 (mitochondrial ribosome-associated), ATP5F1A (ATP synthase subunit alpha, Complex V), COA3 (cytochrome c oxidase assembly factor 3, Complex IV), LAMTOR1 (lysosomal mTOR signaling), STOML2 (stomatin-like 2, mitochondrial inner membrane), MRPL48 (mitochondrial ribosomal protein), NDUFA8 (NADH:ubiquinone oxidoreductase subunit, Complex I), NDUFB9 (Complex I subunit), UQCRC2 (ubiquinol-cytochrome c reductase core protein 2, Complex III), CCNC (cyclin C, CDK8 mediator), SMARCE1 (SWI/SNF chromatin remodeling), APEX1 (DNA repair). The OxPhos genes (ATP5F1A, NDUFA8, NDUFB9, UQCRC2, COA3, DMAC1) are the most coherent sub-theme, supported by STOML2 and MRPL48. This is a mitochondrial OxPhos/respiratory chain module.
Genes
APEX1, ATP5F1A, CCNC, COA3, DMAC1, ESD, HDAC2, HINT2, LAMTOR1, MIEN1, MPST, MRPL48, NDUFA8, NDUFB6, NDUFB9, PTRHD1, RPA2, SMARCE1, SNX17, SPAG7, SSRP1, STOML2, TMED3, UQCRC2
Most correlated modules
- Mitochondrial Metabolic Housekeeping · correlation 0.97
- Mitochondrial OxPhos · correlation 0.95
- Lipid & Isoprenoid Metabolism · correlation 0.94
- Actin Cytoskeletal Regulation · correlation 0.94
- ILC1 Cytoskeletal Metabolic · correlation 0.94
- Mitochondrial Metabolism · correlation 0.93
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.