CCR4 — C-C motif chemokine receptor 4
CCR4 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CCR4's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | T-cell costimulation TCR/AP1/NFKb pathway | ASH1L, BOD1L1, CCM2, CD28, CREBRF, DDX27, ERBIN, ICOS +10 more | View in SCUBA |
About the gene
| Synonyms | CC-CKR-4, CD194, ChemR13, CKR4, CMKBR4, k5-5 |
|---|---|
| Chromosome | 3: 32951644-32956349 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | CD markers, FDA approved drug targets, G-protein coupled receptors, Predicted membrane proteins |
| Molecular function | G-protein coupled receptor, Receptor, Transducer |
Function
High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.