CREBRF — CREB3 regulatory factor
CREBRF belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CREBRF's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Chromatin Modification DNA/chromatin regulation | AKAP13, EPC1, GCC2, GPBP1, JMJD1C, KMT2E, OFD1, PPP1R2 +6 more | View in SCUBA |
| CD4⁺ T cells | T-cell costimulation TCR/AP1/NFKb pathway | ASH1L, BOD1L1, CCM2, CCR4, CD28, DDX27, ERBIN, ICOS +10 more | View in SCUBA |
| Gamma-delta T cells | Innate Stress Signaling Inflammation | AKT3, B4GALT4, BCR, BLOC1S4, COL6A2, DGKQ, ELF2, FAM53B +23 more | |
| Lymphatic endothelial | Stress Kinase Signaling Stress | ATP13A3, CLN8, CYLD, DYRK3, INO80D, IPO5, KLHL21, KMT2A +6 more | View in SCUBA |
| Macrophages | DNA Damage Repair Stress | ABCC5, ADAM28, AKAP9, AKNA, ATM, ATP10D, BAZ2A, CHD9 +27 more | View in SCUBA |
| Mucosal-associated invariant T cell | Metabolic Homeostasis Housekeeping | ADIPOR1, BIRC3, COQ10B, EIF1AX, GNAI3, H2AC20, KLF11, KLHL18 +10 more | |
| Smooth muscle cells | BAG3-HSPB8 proteostasis Stress | BAG3, C6orf62, DNAJB4, EOGT, GOLGB1, HSPB8, IFRD1, PPP2R5E +5 more | View in SCUBA |
About the gene
| Synonyms | C5orf41, LRF |
|---|---|
| Chromosome | 5: 173056352-173139284 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Repressor |
| Biological process | Stress response, Transcription, Transcription regulation, Transport, Unfolded protein response |
Function
Acts as a negative regulator of the endoplasmic reticulum stress response or unfolded protein response (UPR). Represses the transcriptional activity of CREB3 during the UPR. Recruits CREB3 into nuclear foci
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.