CST3 — Cystatin C
CST3 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CST3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | MHC Class II Presentation Inflammation | CD74, CIITA, GSTK1, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DPA1, HLA-DPB1 +7 more | View in SCUBA |
| Enterocytes | Lysosomal/ferritin housekeeping Housekeeping | APLP2, CD164, CRIP1, EDF1, FTH1, FTL, GPA33, ITM2B +5 more | View in SCUBA |
| Fibroblasts | Lysosomal Biogenesis Vesicular traficking | APP, ATRAID, CPQ, GLG1, GRN, HEXA, LGALS3BP, NDN +5 more | View in SCUBA |
| Glial cells | MHC-I Antigen Presentation Inflammation | B2M, BTN3A2, C1R, C1S, HLA-A, HLA-B, HLA-C, IFI27 +4 more | View in SCUBA |
| Goblet cells | Epithelial Maturation Epithelial development | AMN, BAG1, CDC42EP5, KRT10, NTRK2, NXPE4, PHGR1, PPDPF +2 more | View in SCUBA |
| Macrophages | MHC-II Antigen Presentation Innate immunity | AIF1, B2M, C1QA, C1QB, C1QC, CD68, CD74, CTSC +19 more | View in SCUBA |
| Smooth muscle cells | Rho GTPase Housekeeping Housekeeping | CDC42, DDT, OST4, POLR2L, PRELID1, RHOC, SCAND1 | View in SCUBA |
About the gene
| Chromosome | 20: 23626706-23638473 |
|---|---|
| Predicted location | Secreted |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted secreted proteins |
| Molecular function | Protease inhibitor, Thiol protease inhibitor |
Function
As an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.