IFN-γ Metabolic Reprogramming
Gene co-expression module in Colonocytes
| Category | Inflammation |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 12 of 28 genes have a known function matching the annotation |
Why this annotation
Hub genes include PFKP (phosphofructokinase, glycolysis rate-limiting enzyme), SLC2A1 (GLUT1 glucose transporter), IFNGR1 (IFN-γ receptor), ISG20 (interferon-stimulated exonuclease), MAP2K3 (p38 MAPK kinase), PLAUR (uPA receptor), TM4SF1, and FOXO3. The co-expression of glycolytic enzymes (PFKP, SLC2A1) with IFN-γ receptor and ISGs indicates IFN-γ-driven metabolic reprogramming toward aerobic glycolysis (Warburg effect) in inflamed colonocytes. ITGB4 and BAIAP2L1 add cytoskeletal remodeling context. Strongly UC-specific inflammation response.
Genes
Most correlated modules
- TNF Apoptosis Resistance · correlation 0.97
- Basement Membrane Remodeling · correlation 0.95
- Epithelial Junction Integrity · correlation 0.91
- IFN-γ Antiviral Response · correlation 0.91
- Inflamed Barrier Remodeling · correlation 0.90
- Inflammasome Pyroptosis · correlation 0.89
- TGF-β Chromatin Regulation · correlation 0.89
- Senescent Cell Death · correlation 0.87
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.