MHC-II Antigen Presentation
Gene co-expression module in Macrophages
| Category | Innate immunity |
|---|---|
| Genes | 28 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 16 of 28 genes have a known function matching the annotation |
Why this annotation
Hub genes are MHC class II molecules (HLA-DPA1, HLA-DPB1, HLA-DRB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DMA) and CD74 (MHC-II chaperone invariant chain), forming the core antigen presentation machinery. C1QA and C1QC mark complement-expressing tissue-resident macrophages. CD68 and AIF1 (Iba1) are canonical macrophage markers. HLA-A, HLA-B, HLA-C are MHC class I. CYBA is NADPH oxidase subunit. CST3 is cystatin C. The module is enriched in res_mac, consistent with tissue-resident macrophage identity centered on MHC-II antigen presentation.
Genes
AIF1, B2M, C1QA, C1QB, C1QC, CD68, CD74, CST3, CTSC, CYBA, FCER1G, HLA-A, HLA-B, HLA-C, HLA-DMA, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB5, ITM2B, NPC2, TMEM176B, TMSB10, TMSB4X, TPT1
Most correlated modules
- Antimicrobial Oxidative Defense · correlation 0.72
- Inflammasome Oxidative Stress · correlation 0.68
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.